1401731-54-1
1401731-54-1 structure
- Name: MRT00033659
- Chemical Name: MRT00033659
- CAS Number: 1401731-54-1
- Molecular Formula: C15H14N4O
- Molecular Weight: 266.30
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2020-06-01 10:54:06
- Modify Date: 2024-01-10 17:45:20
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MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation[1].
| Name | MRT00033659 |
|---|
| Description | MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation[1]. |
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| Related Catalog | |
| Target |
CKIδ:0.9 μM (IC50) Chk1:0.23 μM (IC50) |
| In Vitro | MRT00033659 (5-40 µM; 48 hours) is sufficient to significantly reduce cell number of 5 µM[1]. MRT00033659 (1-80 µM; 48 hours) induces substantial cell death from 5 µM[1]. MRT00033659 (0.2-80 µM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2 and p21 proteins, as well as E2F-1 destabilisation from 0.2 µM to 5 µM[1]. MRT00033659 does not inhibit p38α MAPK[1]. Cell Viability Assay[1] Cell Line: A375 cells Concentration: 5, 20, 40 µM Incubation Time: 48 hours Result: Significantly reduced cell number of 5 µM. Apoptosis Analysis[1] Cell Line: A375 cells Concentration: 1, 5, 10, 20, 40, 80 µM Incubation Time: 48 hours Result: Induced substantial cell death from 5 µM. Western Blot Analysis[1] Cell Line: A375 cells Concentration: 0.2, 1, 5, 10, 20, 40, 80 µM Incubation Time: 48 hours Result: Induced a robust and sustained stabilisation of p53, MDM2 and p21 proteins, as well as E2F-1 destabilisation from 0.2 µM to 5 µM. |
| References |
| Molecular Formula | C15H14N4O |
|---|---|
| Molecular Weight | 266.30 |