Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TT-OAD2 hydrochloride
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: TT-OAD2 hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2382719-60-8

2382719-60-8 structure

2382719-60-8 structure

Name: TT-OAD2
Chemical Name: TT-OAD2
CAS Number: 2382719-60-8
Molecular Formula: C₅₀H₄₉Cl₄N₃O₆
Molecular Weight: 929.75
Catalog: Signaling Pathways GPCR/G Protein Glucagon Receptor
Create Date: 2020-06-02 02:04:05
Modify Date: 2025-08-25 11:46:07
TT-OAD2 is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 has the potential for diabetes treatment[1][2].

Name	TT-OAD2

Description	TT-OAD2 is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 has the potential for diabetes treatment[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor
Target	EC50: 5 nM (GLP-1 receptor)[2]
In Vitro	TT-OAD2 (0-10 μM) inhibits GLP-1- and oxyntomodulin-mediated cAMP, calcium, pERK1/2 and β-arrestin responses in a concentration-dependent manner in HEK293A cells[1].
In Vivo	TT-OAD2 (3 mg/kg; intravenous injection; male human GLP-1 receptor knock-in and knockout mice) treatment induces plasma insulin in an acute IVGTT on humanized GLP-1R knock-in (KI) and GLP-1R knockout (KO) mice[1]. Animal Model: Male human GLP-1 receptor knock-in and knockout mice (6-11 months of age) with intravenous glucose tolerance tests[1] Dosage: 3 mg/kg Administration: Intravenous injection (Single dose) Result: Induced plasma insulin.
References	[1]. Zhao P, et al. Activation of the GLP-1 receptor by a non-peptidic agonist. Nature. 2020 Jan;577(7790):432-436. [2]. Transtech Pharma, et al. Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof. WO2010114824A1.

Molecular Formula	C₅₀H₄₉Cl₄N₃O₆
Molecular Weight	929.75

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