486443-73-6
486443-73-6 structure
- Name: LC3-mHTT-IN-AN1
- Chemical Name: LC3-mHTT-IN-AN1
- CAS Number: 486443-73-6
- Molecular Formula: C15H9Br2NO3
- Molecular Weight: 411.045
- Create Date: 2020-08-11 06:54:26
- Modify Date: 2024-08-14 23:31:59
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LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
| Name | LC3-mHTT-IN-AN1 |
|---|---|
| Synonyms |
(3Z)-5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-, (3Z)- |
| Density | 2.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 586.1±50.0 °C at 760 mmHg |
| Molecular Formula | C15H9Br2NO3 |
| Molecular Weight | 411.045 |
| Flash Point | 308.3±30.1 °C |
| Exact Mass | 408.894897 |
| LogP | 5.079 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.777 |
| Storage condition | 2-8°C |