2581824-48-6
2581824-48-6 structure
- Name: MMP-9-IN-3
- Chemical Name: MMP-9-IN-3
- CAS Number: 2581824-48-6
- Molecular Formula: C29H25N3O4
- Molecular Weight: 479.53
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-10-12 14:33:42
- Modify Date: 2024-04-09 18:46:01
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MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers[1].
| Name | MMP-9-IN-3 |
|---|
| Description | MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers[1]. |
|---|---|
| Related Catalog | |
| Target |
MMP-9:5.56 nM (IC50) MMP-1:447 nM (IC50) MMP-2:221 nM (IC50) MMP13:295 nM (IC50) AKT:2.11 nM (IC50) |
| In Vitro | MMP-9-IN-3 (compound 28, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1]. MMP-9-IN-3 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.6 nM, 5.8 nM, 5.7 nM respectively[1]. MMP-9-IN-3 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.6 nM, 5.8 nM, 5.7 nM respectively[1]. MMP-9-IN-3 (5.7 nM, 24 h) inhibits cell migration in HepG-2 cells[1]. Cell Viability Assay[1] Cell Line: Wi-38, MCF-7, NFS-60, HepG-2 cells Concentration: 0-1 μM approximately Incubation Time: 72 h Result: Showed cytotoxicity with IC50: 314 nM (Wi-38), 6.6 nM (MCF-7), 5.8 nM (NFS-60), 5.7 nM (HepG-2). Cell Migration Assay [1] Cell Line: HepG-2 Concentration: 5.7 nM Incubation Time: 24 h Result: Inhibited cell migration by 71.25%. |
| References |
| Molecular Formula | C29H25N3O4 |
|---|---|
| Molecular Weight | 479.53 |