2411382-24-4
2411382-24-4 structure
- Name: CAY10756
- Chemical Name: ASK1-IN-1
- CAS Number: 2411382-24-4
- Molecular Formula: C19H19N9O2
- Molecular Weight: 405.41
- Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
- Create Date: 2020-08-08 16:56:57
- Modify Date: 2024-01-16 19:05:12
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ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM)[1].
| Name | ASK1-IN-1 |
|---|
| Description | ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 138/21 nM (ASK1 in cell and Biochemical assays, respectively)[1] |
| In Vitro | ASK1-IN-1 (compound 21) has superior CYP inhibition profile and it is also inactive in a hERG assay. ASK1-IN-1 is selected for a kinase selectivity profile against a panel of 468 kinases and it is found to be moderately selective[1]. |
| In Vivo | ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC50/IC70/IC90 at trough in the brain for 12 hours of 50/115/435 mg/kg respectively. ASK1-IN-1 has good biochemical and cellular potency, low clearance and good brain penetration in rodents[1]. |
| References |
| Molecular Formula | C19H19N9O2 |
|---|---|
| Molecular Weight | 405.41 |