JNJ 5207852 dihydrochloride

Modify Date: 2024-01-09 22:13:03

JNJ 5207852 dihydrochloride structure	Common Name	JNJ 5207852 dihydrochloride
	CAS Number	1782228-76-5	Molecular Weight	389.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₃₄Cl₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JNJ 5207852 dihydrochloride

JNJ-5207852 dihydrochloride is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.

Name	JNJ-5207852 dihydrochloride

Description	JNJ-5207852 dihydrochloride is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H3 Receptor:8.9 (pKi, for rat) H3 Receptor:9.24 (pKi, for human)
In Vivo	JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels[1]. Animal Model: Male, Sprague-Dawley rats weighing 282-334 g[1]. Dosage: 3, 10, 30 mg/kg. Administration: S.C. Result: Iincreased time spent awake and decreased REM sleep and slow-wave sleep.
References	[1]. Barbier AJ, et al. Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61. [2]. Abuhamdah RM, et al. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze. Front Syst Neurosci. 2012 Jul 16;6:54.

Molecular Formula	C₂₀H₃₄Cl₂N₂O
Molecular Weight	389.40

Hazard Codes	Xn

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: JNJ 5207852 dihydrochloride
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

JNJ 5207852 dihydrochloride suppliers

JNJ 5207852 dihydrochloride price