915082-52-9
915082-52-9 structure
- Name: A 33
- Chemical Name: PDE4B-IN-2
- CAS Number: 915082-52-9
- Molecular Formula: C19H18ClN3O2S
- Molecular Weight: 387.88
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2020-08-10 19:09:41
- Modify Date: 2024-01-13 20:10:52
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PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects.
| Name | PDE4B-IN-2 |
|---|
| Description | PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects. |
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| Related Catalog |
| Molecular Formula | C19H18ClN3O2S |
|---|---|
| Molecular Weight | 387.88 |