A 33 structure
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Common Name | A 33 | ||
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CAS Number | 915082-52-9 | Molecular Weight | 387.88 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C19H18ClN3O2S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of A 33PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects. |
Name | PDE4B-IN-2 |
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Description | PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects. |
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Related Catalog |
Molecular Formula | C19H18ClN3O2S |
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Molecular Weight | 387.88 |