A 33
Modify Date: 2024-01-13 20:10:52
A 33 structure
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Common Name | A 33 | ||
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| CAS Number | 915082-52-9 | Molecular Weight | 387.88 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H18ClN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of A 33PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects. |
| Name | PDE4B-IN-2 |
|---|
| Description | PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects. |
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| Related Catalog |
| Molecular Formula | C19H18ClN3O2S |
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| Molecular Weight | 387.88 |