1807758-81-1

1807758-81-1 structure

Name: SIRT7 inhibitor 97491
Chemical Name: SIRT7 inhibitor 97491
CAS Number: 1807758-81-1
Molecular Formula: C₁₅H₁₂ClN₃O
Molecular Weight: 285.73
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2020-08-08 18:17:34
Modify Date: 2024-01-03 16:30:43
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].

Name	SIRT7 inhibitor 97491

Description	SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT7:325 nM (IC50)
In Vitro	SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1]. Cell Proliferation Assay[1] Cell Line: Human uterine sarcoma MES-SA cells Concentration: 1, 5, 10 μM Incubation Time: 72 hours Result: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay[1] Cell Line: Human embryonic kidney cell line HEK293 cells Concentration: 1, 5, 10 μM Incubation Time: 24 hours Result: HEK293 cells were almost unaffected.
In Vivo	SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1]. Animal Model: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1] Dosage: 2 mg/kg Administration: Intraperitoneally injected; for 3 weeks, except on weekends. Result: Inhibited cancer growth in vivo.
References	[1]. Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.

Molecular Formula	C₁₅H₁₂ClN₃O
Molecular Weight	285.73

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1807758-81-1	1235449-52-1
2130878-25-8	2097938-64-0
54642-23-8	579492-83-4
1646784-47-5	223532-02-3
1275482-57-9	847256-33-1
1261486-48-9	1805706-61-9
1361782-09-3	1361751-48-5
1806597-49-8	1361845-32-0
1805889-74-0	1806275-39-7
1803849-56-0	1806962-15-1