1446322-66-2
1446322-66-2 structure
- Name: TAT-cyclo-CLLFVY TFA
- Chemical Name: TAT-cyclo-CLLFVY
- CAS Number: 1446322-66-2
- Molecular Formula: C116H176N32O33
- Molecular Weight: 2546.86
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
- Create Date: 2020-08-11 00:06:29
- Modify Date: 2024-01-14 20:25:21
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TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces tubularization of hypoxic HUVECs.
| Name | TAT-cyclo-CLLFVY |
|---|
| Description | TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces tubularization of hypoxic HUVECs. |
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| Related Catalog |
| Molecular Formula | C116H176N32O33 |
|---|---|
| Molecular Weight | 2546.86 |
| Hazard Codes | Xi |
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