TAT-cyclo-CLLFVY TFA
Modify Date: 2024-01-14 20:25:21
TAT-cyclo-CLLFVY TFA structure
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Common Name | TAT-cyclo-CLLFVY TFA | ||
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| CAS Number | 1446322-66-2 | Molecular Weight | 2546.86 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C116H176N32O33 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TAT-cyclo-CLLFVY TFATAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces tubularization of hypoxic HUVECs. |
| Name | TAT-cyclo-CLLFVY |
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| Description | TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces tubularization of hypoxic HUVECs. |
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| Related Catalog |
| Molecular Formula | C116H176N32O33 |
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| Molecular Weight | 2546.86 |
| Hazard Codes | Xi |
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