TAT-cyclo-CLLFVY TFA

Modify Date: 2024-01-14 20:25:21

TAT-cyclo-CLLFVY TFA Structure
TAT-cyclo-CLLFVY TFA structure
Common Name TAT-cyclo-CLLFVY TFA
CAS Number 1446322-66-2 Molecular Weight 2546.86
Density N/A Boiling Point N/A
Molecular Formula C116H176N32O33 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TAT-cyclo-CLLFVY TFA


TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces tubularization of hypoxic HUVECs.

 Names

Name TAT-cyclo-CLLFVY

 TAT-cyclo-CLLFVY TFA Biological Activity

Description TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. TAT-cyclo-CLLFVY blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50=1.3 μM). TAT-cyclo-CLLFVY inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. TAT-cyclo-CLLFVY also reduces tubularization of hypoxic HUVECs.
Related Catalog

 Chemical & Physical Properties

Molecular Formula C116H176N32O33
Molecular Weight 2546.86

 Safety Information

Hazard Codes Xi