1258294-34-6
1258294-34-6 structure
- Name: TC JL 37
- Chemical Name: TCJL37
- CAS Number: 1258294-34-6
- Molecular Formula: C17H11ClF2N4O2
- Molecular Weight: 376.74
- Catalog: Signaling Pathways Epigenetics JAK
- Create Date: 2020-08-08 07:37:39
- Modify Date: 2025-08-21 08:19:34
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TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD)[1].
| Name | TCJL37 |
|---|
| Description | TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD)[1]. |
|---|---|
| Related Catalog | |
| Target |
Tyk2:1.6 nM (Ki) |
| In Vitro | In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nM In human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively[1]. |
| In Vivo | TCJL37 exhibits excellent oral exposure in CD-1 mice following oral administration (100 mg/kg). TCJL37 exhibits low clearance (1.0 mL/min/kg) in rat[1]. |
| References |
| Molecular Formula | C17H11ClF2N4O2 |
|---|---|
| Molecular Weight | 376.74 |