123168-46-7

123168-46-7 structure

Name: Melittin (free acid) trifluoroacetate salt
Chemical Name: Melittin (free acid) trifluoroacetate salt
CAS Number: 123168-46-7
Molecular Formula: C₁₃₁H₂₂₈N₃₈O₃₂
Molecular Weight: 2847.448
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2020-11-14 18:34:48
Modify Date: 2025-08-25 14:42:06
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].

Name	Melittin (free acid) trifluoroacetate salt
Synonyms	L-Glutamine, glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl- Glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-L-glutamine

Description	Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Melittin free acid 刺激小鼠纤维细胞 (MC5-5)、人成纤维细胞 (D550)、兔主动脉内皮细胞 (CLO)、大鼠肺型肺泡肺细胞 (L-2) 和兔平滑肌细胞 (R-I) 的前列腺素生物合成[1]。 Melittin free acid 刺激 MC5-5 细胞磷脂中花生四烯酸的释放[1]。 Melittin free acid 诱导黄曲霉萌发分生孢子中活性氧的积累[2]。 Melittin 抑制灰霉菌 MUCL 30158 和 CECT 2100 菌株，IC50 值分别为 3.1 和 24 μM[2]。
In Vivo	Melittin (腹腔内接种) 可增加小鼠外周血中 13,14-dihydro-15-keto-PGE2 的水平[1]。
References	[1]. Hassid A, Levine L. Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Pathol Pharmacol. 1977. [2]. Memariani H, Memariani M. Anti-fungal properties and mechanisms of melittin. Appl Microbiol Biotechnol. 2020 Aug;104(15):6513-6526.

Density	1.4±0.1 g/cm3
Molecular Formula	C₁₃₁H₂₂₈N₃₈O₃₂
Molecular Weight	2847.448
Exact Mass	2845.738281
LogP	-0.28
Index of Refraction	1.634

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