2089205-64-9

2089205-64-9 structure

Name: PROTAC RIPK degrader-6
Chemical Name: PROTAC RIPK degrader-6
CAS Number: 2089205-64-9
Molecular Formula: C₄₃H₄₈N₆O₁₁S₂
Molecular Weight: 889.00
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2020-10-20 11:45:54
Modify Date: 2024-01-19 10:48:52
PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].

Name	PROTAC RIPK degrader-6

Description	PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> RIP kinase Signaling Pathways >> PROTAC >> PROTAC
Target	Cereblon
In Vitro	PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation[1].
References	[1]. John David Harlin, et al. Compounds for the modulation of rip2 kinase activity. WO2017046036A1.