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1638178-82-1

1638178-82-1 structure
1638178-82-1 structure
  • Name: ONC-201 Dihydrochloride
  • Chemical Name: ONC-201 DIHYDROCHLORIDE
  • CAS Number: 1638178-82-1
  • Molecular Formula: C24H28Cl2N4O
  • Molecular Weight: 459.411
  • Create Date: 2021-01-07 17:53:11
  • Modify Date: 2025-08-26 23:13:54
  • ONC-201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.

Name ONC-201 DIHYDROCHLORIDE
Synonyms Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-, hydrochloride (1:2)
7-Benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one dihydrochloride
ONC-201 DIHYDROCHLORIDE
Molecular Formula C24H28Cl2N4O
Molecular Weight 459.411
Exact Mass 458.164032
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