1458031-48-5
1458031-48-5 structure
- Name: RUSKI-201
- Chemical Name: 2-[(2-Methylbutyl)amino]-1-[4-(6-methyl-2-pyridinyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]ethanone
- CAS Number: 1458031-48-5
- Molecular Formula: C20H27N3OS
- Molecular Weight: 357.513
- Create Date: 2020-01-11 17:13:51
- Modify Date: 2025-08-26 23:28:40
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A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM; blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively); selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.
| Name | 2-[(2-Methylbutyl)amino]-1-[4-(6-methyl-2-pyridinyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]ethanone |
|---|---|
| Synonyms |
Ethanone, 1-[6,7-dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-
2-[(2-Methylbutyl)amino]-1-[4-(6-methyl-2-pyridinyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]ethanone |
| Description | A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM; blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively); selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells. |
|---|---|
| References | References 1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. View Related Products by Target Hedgehog (Hh) |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 520.7±50.0 °C at 760 mmHg |
| Molecular Formula | C20H27N3OS |
| Molecular Weight | 357.513 |
| Flash Point | 268.7±30.1 °C |
| Exact Mass | 357.187469 |
| LogP | 3.26 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.576 |