216657-60-2

216657-60-2 structure

Name: AR-C 118925XX
Chemical Name: AR-C118925XX
CAS Number: 216657-60-2
Molecular Formula: C₂₈H₂₃N₇O₃S
Molecular Weight: 537.592
Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
Create Date: 2021-01-10 10:15:37
Modify Date: 2024-01-05 16:36:47
AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2].

Name	AR-C118925XX
Synonyms	AR-C118925XX 2-Furancarboxamide, 5-[[5-(2,8-dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-1H-tetrazol-5-yl- 5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d][7]annulen-5-yl)-2-oxo-4-thioxo-3,4-dihydro-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furamide

Description	AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Inflammation/Immunology
Target	P2Y2 Receptor
In Vivo	AR-C118925XX (i.p.) 抑制 Bleomycin 对小鼠真皮厚度的增加[1]。
References	[1]. Perera LMB, et al. The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y2 Purinergic Receptor. J Invest Dermatol. 2019 Apr;139(4):890-899. [2]. Dong CR, et al. AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer. Carcinogenesis. 2022 Dec 5:bgac095.