AR-C 118925XX

Modify Date: 2024-01-05 16:36:47

AR-C 118925XX Structure
AR-C 118925XX structure
Common Name AR-C 118925XX
CAS Number 216657-60-2 Molecular Weight 537.592
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C28H23N7O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AR-C 118925XX


AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2].

 Names

Name AR-C118925XX
Synonym More Synonyms

 AR-C 118925XX Biological Activity

Description AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2].
Related Catalog
Target

P2Y2 Receptor

In Vivo AR-C118925XX (i.p.) 抑制 Bleomycin 对小鼠真皮厚度的增加[1]。
References

[1]. Perera LMB, et al. The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y2 Purinergic Receptor. J Invest Dermatol. 2019 Apr;139(4):890-899.  

[2]. Dong CR, et al. AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer. Carcinogenesis. 2022 Dec 5:bgac095.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C28H23N7O3S
Molecular Weight 537.592
Exact Mass 537.158325
LogP 4.78
Index of Refraction 1.756

 Synonyms

AR-C118925XX
2-Furancarboxamide, 5-[[5-(2,8-dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-1H-tetrazol-5-yl-
5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d][7]annulen-5-yl)-2-oxo-4-thioxo-3,4-dihydro-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furamide