183499-56-1
183499-56-1 structure
- Name: L778123 dihydrochloride
- Chemical Name: L778123 dihydrochloride
- CAS Number: 183499-56-1
- Molecular Formula: C22H22Cl3N5O
- Molecular Weight: 478.802
- Create Date: 2021-01-08 10:44:31
- Modify Date: 2024-01-06 07:27:31
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L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.
| Name | L778123 dihydrochloride |
|---|
| Description | L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed. |
|---|
| Molecular Formula | C22H22Cl3N5O |
|---|---|
| Molecular Weight | 478.802 |