L778123 dihydrochloride

Modify Date: 2024-01-06 07:27:31

L778123 dihydrochloride Structure
L778123 dihydrochloride structure
Common Name L778123 dihydrochloride
CAS Number 183499-56-1 Molecular Weight 478.802
Density N/A Boiling Point N/A
Molecular Formula C22H22Cl3N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of L778123 dihydrochloride


L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

 Names

Name L778123 dihydrochloride

 L778123 dihydrochloride Biological Activity

Description L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

 Chemical & Physical Properties

Molecular Formula C22H22Cl3N5O
Molecular Weight 478.802