2376255-48-8
2376255-48-8 structure
- Name: Ac-FLTD-CMK
- Chemical Name: Ac-FLTD-CMK
- CAS Number: 2376255-48-8
- Molecular Formula: C26H37ClN4O8
- Molecular Weight: 569.05
- Catalog: Signaling Pathways Apoptosis Caspase
- Create Date: 2021-01-06 23:51:01
- Modify Date: 2024-01-08 11:22:41
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Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1].
| Name | Ac-FLTD-CMK |
|---|
| Description | Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3[1]. |
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| Related Catalog | |
| Target |
Caspase-1:46.7 nM (IC50) Caspase-4:1.49 μM (IC50) Caspase-5:329 nM (IC50) Caspase-11 |
| In Vitro | Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts[1]. |
| References |
| Molecular Formula | C26H37ClN4O8 |
|---|---|
| Molecular Weight | 569.05 |
| Hazard Codes | Xi |
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