1329809-23-5
1329809-23-5 structure
- Name: Dronedarone-d6 (hydrochloride)
- Chemical Name: Dronedarone-d6 (hydrochloride)
- CAS Number: 1329809-23-5
- Molecular Formula: C31H39D6ClN2O5S
- Molecular Weight: 599.254
- Catalog: Signaling Pathways Autophagy Autophagy
- Create Date: 2021-06-12 09:38:14
- Modify Date: 2024-01-10 10:11:53
-
Dronedarone D6 hydrochloride is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4].
| Name | Dronedarone-d6 (hydrochloride) |
|---|---|
| Synonyms |
N-[2-Butyl-3-(4-{[3-(dibutylamino)(2H6)propyl]oxy}benzoyl)-1-benzofuran-5-yl]methanesulfonamide hydrochloride (1:1)
Methanesulfonamide, N-[2-butyl-3-[4-[[3-(dibutylamino)propyl-1,1,2,2,3,3-d6]oxy]benzoyl]-5-benzofuranyl]-, hydrochloride (1:1) Dronedarone-d6 (hydrochloride) |
| Description | Dronedarone D6 hydrochloride is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4]. |
|---|---|
| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
[2]. Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120(7):636-44. |
| Molecular Formula | C31H39D6ClN2O5S |
|---|---|
| Molecular Weight | 599.254 |
| Exact Mass | 598.311401 |