Dronedarone-d6 (hydrochloride)

Modify Date: 2024-01-10 10:11:53

Dronedarone-d6 (hydrochloride) structure	Common Name	Dronedarone-d6 (hydrochloride)
	CAS Number	1329809-23-5	Molecular Weight	599.254
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₉D₆ClN₂O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dronedarone-d6 (hydrochloride)

Dronedarone D6 hydrochloride is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4].

Name	Dronedarone-d6 (hydrochloride)
Synonym	More Synonyms

Description	Dronedarone D6 hydrochloride is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4[1][2][3][4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120(7):636-44. [3]. Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna). 2019 Feb;126(2):115-122.

Molecular Formula	C₃₁H₃₉D₆ClN₂O₅S
Molecular Weight	599.254
Exact Mass	598.311401

N-[2-Butyl-3-(4-{[3-(dibutylamino)(2H6)propyl]oxy}benzoyl)-1-benzofuran-5-yl]methanesulfonamide hydrochloride (1:1)

Methanesulfonamide, N-[2-butyl-3-[4-[[3-(dibutylamino)propyl-1,1,2,2,3,3-d6]oxy]benzoyl]-5-benzofuranyl]-, hydrochloride (1:1)

Dronedarone-d6 (hydrochloride)

DC Chemicals Limited
China
Product Name: Dronedarone D6 hydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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