927635-64-1
927635-64-1 structure
- Name: HA-14-1
- Chemical Name: HA-14-1
- CAS Number: 927635-64-1
- Molecular Formula: C17H17BrN2O5
- Molecular Weight: 409.231
- Create Date: 2021-05-07 13:32:45
- Modify Date: 2024-02-24 18:31:51
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HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 M) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3.
| Name | HA-14-1 |
|---|---|
| Synonyms |
Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate
Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester MFCD00218213 MFCD22200055 HA14-1 HA-14-1 4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester HA 14-1 |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 535.1±50.0 °C at 760 mmHg |
| Molecular Formula | C17H17BrN2O5 |
| Molecular Weight | 409.231 |
| Flash Point | 277.4±30.1 °C |
| Exact Mass | 408.032074 |
| LogP | 3.70 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.574 |