927635-64-1

• 常用中文名：HA-14-1
• 常用英文名：HA-14-1
• CAS号：927635-64-1
• 分子式：C₁₇H₁₇BrN₂O₅
• 分子量：409.231
• 发布时间：2021-05-07 13:32:45
• 更新时间：2024-02-24 18:31:51
• HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 M) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3.

名称

• 英文名: HA-14-1
• 英文别名: Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate; Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate; 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester; MFCD00218213; MFCD22200055; HA14-1; HA-14-1; 4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester; 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester; HA 14-1

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 535.1±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₇BrN₂O₅
• 分子量: 409.231
• 闪点: 277.4±30.1 °C
• 精确质量: 408.032074
• LogP: 3.70
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.574
• 储存条件: -20°C，密闭，干燥