1204572-55-3
1204572-55-3 structure
- Name: BPAM344
- Chemical Name: BPAM344
- CAS Number: 1204572-55-3
- Molecular Formula: C10H11FN2O2S
- Molecular Weight: 242.270
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2021-09-10 08:04:18
- Modify Date: 2024-01-09 22:37:35
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BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1].
| Name | BPAM344 |
|---|---|
| Synonyms |
4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide
2H-1,2,4-Benzothiadiazine, 4-cyclopropyl-7-fluoro-3,4-dihydro-, 1,1-dioxide 4-Cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide BPAM344 |
| Description | BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics[1]. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 415.9±55.0 °C at 760 mmHg |
| Molecular Formula | C10H11FN2O2S |
| Molecular Weight | 242.270 |
| Flash Point | 205.3±31.5 °C |
| Exact Mass | 242.052521 |
| LogP | 0.69 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.635 |
| Hazard Codes | Xn |
|---|