BPAM344

Modify Date: 2024-01-09 22:37:35

BPAM344 structure	Common Name	BPAM344
	CAS Number	1204572-55-3	Molecular Weight	242.270
	Density	1.5±0.1 g/cm3	Boiling Point	415.9±55.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₁FN₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	205.3±31.5 °C

Use of BPAM344

BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1].

Name	BPAM344
Synonym	More Synonyms

Description	BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics[1]. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1].
References	[1]. Anja Probst Larsen, et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol Pharmacol. 2017 Jun;91(6):576-585.

Density	1.5±0.1 g/cm3
Boiling Point	415.9±55.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₁FN₂O₂S
Molecular Weight	242.270
Flash Point	205.3±31.5 °C
Exact Mass	242.052521
LogP	0.69
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.635

Hazard Codes	Xn

4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide

2H-1,2,4-Benzothiadiazine, 4-cyclopropyl-7-fluoro-3,4-dihydro-, 1,1-dioxide

4-Cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

BPAM344

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BPAM344
Price:
Purity: 98.0%
Stocking Period: Inquiry
Contact: Tom

DC Chemicals Limited
China
Product Name: BPAM344
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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