207732-11-4

207732-11-4 structure

Name: BB-78485
Chemical Name: N-Hydroxy-3-(2-naphthyl)-N2-(2-naphthylsulfonyl)-D-alaninamide
CAS Number: 207732-11-4
Molecular Formula: C₂₃H₂₀N₂O₄S
Molecular Weight: 420.48
Create Date: 2021-09-10 21:24:26
Modify Date: 2024-04-07 12:06:51
BB-78485 is an LpxC metalloenzyme inhibitor with antibacterial activity. BB-78485 can inhibit LpxC with an IC50 value of 160 nM. BB-78485 can be used for the research of gram-negative selective antibacterials[1].

Name	N-Hydroxy-3-(2-naphthyl)-N2-(2-naphthylsulfonyl)-D-alaninamide
Synonyms	(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide N-Hydroxy-3-(2-naphthyl)-N2-(2-naphthylsulfonyl)-D-alaninamide 2-Naphthalenepropanamide, N-hydroxy-α-[(2-naphthalenylsulfonyl)amino]-, (αR)- BB-78485

Description	BB-78485 is an LpxC metalloenzyme inhibitor with antibacterial activity. BB-78485 can inhibit LpxC with an IC50 value of 160 nM. BB-78485 can be used for the research of gram-negative selective antibacterials[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 160 nM(LpxC)[1]
In Vitro	BB-78485 可以抑制 LpxC，IC50 值为 160 nM[1]。 BB-78485 对 D21 和 D22 (lpxC101) 有作用，MIC 值分别为 2 μg/mL 和 0.016 μg/mL[1]。 BB-78485 对Enterobacteriaceae, Serratia marcescens, Morganella morganii, Moraxella catarrhalis, Haemophilus influenzae和 Burkholderia cepacia的 MIC 值范围为 1μg/mL 至 32μg/mL[1]。
References	[1]. Clements JM, et al. Antibacterial activities and characterization of novel inhibitors of LpxC. Antimicrob Agents Chemother. 2002;46(6):1793-1799.