2249435-90-1
2249435-90-1 structure
- Name: SN-011
- Chemical Name: STING inhibitor-1
- CAS Number: 2249435-90-1
- Molecular Formula: C25H19FN2O4S
- Molecular Weight: 462.49
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2021-09-28 13:48:00
- Modify Date: 2025-08-22 18:23:42
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SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease[1].
| Name | STING inhibitor-1 |
|---|---|
| Synonyms | [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]- |
| Description | SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease[1]. |
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| Related Catalog | |
| Target |
IC50: 76 nM (STING signaling)[1] |
| In Vitro | SN-011 (1 μM; pretreated for 6 h) significantly suppresses the STING stimulator-induced expression of Ifnb, Cxcl10, and Il6 mRNA in mouse embryonic fibroblasts (MEFs)[1]. SN-011 (0.001-10 μM; pretreated for 6 h) inhibits 2′3′-cGAMP-induced Ifnb expression in MEFs, mouse bone marrow-derived macrophages (BMDMs) and human foreskin fibroblasts (HFFs) with IC50s of 127.5, 107.1, and 502.8 nM, respectively[1]. SN-011 (1 μM; pretreated for 3 h) inhibits 2′3′-cGAMP-induced STING oligomerization and phosphorylation in HFFs[1]. SN-011 (1 μM) suppresses HSV-1 infection (4 h), HT-DNA (1 h), or 2′3′-cGAMP stimulation (30 min) induced STING ER-to-Golgi translocation[1]. Western Blot Analysis[1] Cell Line: Human foreskin fibroblasts Concentration: 1 μM Incubation Time: Pretreated and then stimulated with 2′3′-cGAMP for 1 h Result: Suppressed 2′3′-cGAMP-induced STING oligomerization and phosphorylation. |
| In Vivo | SN-011 (5 mg/kg; i.p. 3 times weekly for a month) strongly inhibits hallmarks of inflammation and autoimmunity disease, and protects Trex1−/− mice from death[1]. Animal Model: 4-wk-old Trex1−/− mice[1] Dosage: 5 mg/kg Administration: I.p. 3 times weekly for a month Result: Improved survival of mice. Reduced severe multiorgan inflammation. Reduced serum antinuclear antibody. |
| References |
| Molecular Formula | C25H19FN2O4S |
|---|---|
| Molecular Weight | 462.49 |