Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Linuron
Price: ￥298.0/100mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Linuron
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

330-55-2

330-55-2 structure

Name: Linuron
Chemical Name: linuron
CAS Number: 330-55-2
Molecular Formula: C₉H₁₀Cl₂N₂O₂
Molecular Weight: 249.094
Catalog: Chemical pesticide herbicide Other herbicides
Create Date: 2018-09-18 17:06:43
Modify Date: 2025-08-20 08:18:06
Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor[1][2][3][4].

Name	linuron
Synonyms	Lorex EINECS 206-356-5 3-(3,4-Dichlorophenyl)-1-methoxy-1-methylurea Linuron Laroks Urea, N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl- AFALON LOROX MFCD00055249 Afolan Liron Methanol, 1-[(3,4-dichlorophenyl)imino]-1-(methoxymethylamino)-, (E)- LINEX LINNET N’-(3,4-dichlorophenyl)-N-methoxy-N-methylurea LINUREX

Description	Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor[1][2][3][4].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Androgen Receptor
Target	Ki: 100 μM (Androgen receptor)[2] Photosystem II[4]
References	[1]. Benjamin Horemans, et al. Functional Redundancy of Linuron Degradation in Microbial Communities in Agricultural Soil and Biopurification Systems. Appl Environ Microbiol. 2016 Apr 18;82(9):2843-2853. [2]. C Lambright, et al. Cellular and Molecular Mechanisms of Action of Linuron: An Antiandrogenic Herbicide That Produces Reproductive Malformations in Male Rats. Toxicol Sci. 2000 Aug;56(2):389-99. [3]. Hongwei Ding, et al. Reproductive Toxicity of Linuron Following Gestational Exposure in Rats and Underlying Mechanisms. Toxicol Lett. 2017 Jan 15;266:49-55. [4]. Elżbieta G Magnucka, et al. Various Effects of the Photosystem II--inhibiting Herbicides on 5-n-alkylresorcinol Accumulation in Rye Seedlings. Pestic Biochem Physiol. 2014 Nov;116:56-62.

Density	1.3±0.1 g/cm3
Boiling Point	361.7±52.0 °C at 760 mmHg
Melting Point	93-94°C
Molecular Formula	C₉H₁₀Cl₂N₂O₂
Molecular Weight	249.094
Flash Point	172.6±30.7 °C
Exact Mass	248.011932
PSA	41.57000
LogP	3.33
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.556
Water Solubility	0.0075 g/100 mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS9100000

CHEMICAL NAME :: Urea, 3-(3,4-dichlorophenyl)-1-methoxy-1-methyl-

CAS REGISTRY NUMBER :: 330-55-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C9-H10-Cl2-N2-O2

MOLECULAR WEIGHT :: 249.11

WISWESSER LINE NOTATION :: GR BG DMVN1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1146 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 3765 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/60D-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1070 mg/kg/31W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 gm/kg/10D-I

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 7500 mg/kg/30D-I

TOXIC EFFECTS :: Behavioral - muscle weakness Cardiac - EKG changes not diagnostic of specified effects Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1750 mg/kg/7D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Related to Chronic Data - death

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,353,1978 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

Symbol	GHS07, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H302-H351-H360Df-H373-H410
Precautionary Statements	P201-P273-P281-P308 + P313-P501
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	N,T,F
Risk Phrases	R61
Safety Phrases	S53-S45-S60-S61-S36/37
RIDADR	UN 3077
RTECS	YS9100000
HS Code	2928000032

102-36-3

330-55-2

Literature: Angewandte Chemie, , vol. 75, p. 851 - 854

17356-61-5

77-78-1

330-55-2

Literature: Angewandte Chemie, , vol. 75, p. 851 - 854

31225-17-9

77-78-1

330-55-2

Literature: Angewandte Chemie, , vol. 75, p. 851 - 854

Precursor 4
102-36-3 17356-61-5 77-78-1 31225-17-9
DownStream 1
74-89-5

HS Code	2928000032
Summary	2928000032 3-(4-bromo-3-chlorophenyl)-1-methoxy-1-methylurea。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

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