Name | Loratadine |
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Synonyms |
MFCD00672869
ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate CLARATYNE Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate Ethyl-4-(8-chlor-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yliden)piperidin-1-carboxylat 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester Loratadine Flonidan Claritine Loranox CLARITIN Tadine Klaritin Civeran Clarityn Cronopen Lisino 11-[N-(Ethoxycarbonyl)-4-piperidylidene]-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine |
Description | Loratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.IC50 value: 32 uMTarget: H1-receptorLoratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. |
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Related Catalog | |
References |
[3]. Monroe EW. Loratadine in the treatment of urticaria. Clin Ther. 1997 Mar-Apr;19(2):232-42. |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 531.3±50.0 °C at 760 mmHg |
Melting Point | 134-136°C |
Molecular Formula | C22H23ClN2O2 |
Molecular Weight | 382.883 |
Flash Point | 275.1±30.1 °C |
Exact Mass | 382.144806 |
PSA | 42.43000 |
LogP | 5.94 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.614 |
Storage condition | 2-8°C |
Stability | Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents. |
Water Solubility | DMSO: 26 mg/mL, soluble |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi |
Risk Phrases | R36/37/38 |
Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 2 |
HS Code | 2933990090 |
Precursor 10 | |
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DownStream 2 | |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |