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117796-52-8 1227675-51-5
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117796-52-8

117796-52-8 structure
117796-52-8 structure
  • Name: Sch 37370
  • Chemical Name: 1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone
  • CAS Number: 117796-52-8
  • Molecular Formula: C21H21ClN2O
  • Molecular Weight: 352.85700
  • Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
  • Create Date: 2017-06-18 05:05:30
  • Modify Date: 2024-01-08 21:40:59
  • N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].
Name 1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone
Synonyms N-Acetyldesloratadine
PegCNTF
RESPATADINE
Loratadine Impurity 11
Description N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].
Related Catalog
References

[1]. Billah MM, et, al. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26(12):1172-4.  

Density 1.257g/cm3
Boiling Point 546.9ºC at 760mmHg
Molecular Formula C21H21ClN2O
Molecular Weight 352.85700
Flash Point 284.5ºC
Exact Mass 352.13400
PSA 33.20000
LogP 4.21570
Vapour Pressure 5.15E-12mmHg at 25°C
Index of Refraction 1.626
Storage condition -20°C
100643-71-8 structure

100643-71-8
75-36-5 structure

75-36-5

~%

117796-52-8 structure

117796-52-8
Literature: Mu, Shuai; Xie, Xiao-Shuai; Niu, Duan; Zhang, Da-Shuai; Liu, Deng-Ke; Liu, Chang-Xiao Chinese Chemical Letters, 2013 , vol. 24, # 6 p. 531 - 534
108-24-7 structure

108-24-7
100643-71-8 structure

100643-71-8

~81%

117796-52-8 structure

117796-52-8
Literature: Mezei, Tibor; Volk, Balazs; Kiraly, Imre; Simig, Gyula Organic Process Research and Development, 2008 , vol. 12, # 5 p. 855 - 859
32998-95-1 structure

32998-95-1

~%

117796-52-8 structure

117796-52-8
Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
31255-57-9 structure

31255-57-9

~%

117796-52-8 structure

117796-52-8
Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
107285-30-3 structure

107285-30-3

~%

117796-52-8 structure

117796-52-8
Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
130642-50-1 structure

130642-50-1

~%

117796-52-8 structure

117796-52-8
Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
79794-75-5 structure

79794-75-5

~%

117796-52-8 structure

117796-52-8
Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
620-20-2 structure

620-20-2

~%

117796-52-8 structure

117796-52-8
Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
38092-89-6 structure

38092-89-6

~%

117796-52-8 structure

117796-52-8
Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461

Chemsrc provides CAS#:117796-52-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 117796-52-8 | Chemsrc address: https://m.chemsrc.com/en/baike/768106.html

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