117796-52-8
117796-52-8 structure
- Name: Sch 37370
- Chemical Name: 1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone
- CAS Number: 117796-52-8
- Molecular Formula: C21H21ClN2O
- Molecular Weight: 352.85700
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2017-06-18 05:05:30
- Modify Date: 2026-07-01 20:29:09
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N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].
| Name | 1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone |
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| Synonyms |
RESPATADINE
1-Acetyl-4-[(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohta[1,2-b]pyridin)-11-ylidene]piperidine N-AcylImpurity 1-[4-[(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohta[1,2-b]pyridine)-11-ylidene]piperidino]ethanone 1-(4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohta[1,2-b]pyridin-11-ylidene)piperidin-1-yl)ethan-1-one N-Acetyldesloratadine N-Acetyldesloratadine (Desloratadine Impurity) Ethanone, 1-[4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohta[1,2-b]pyridin-11-ylidene)-1-piperidinyl] Sch 37370 //BP N-Acetyl Desloratadine SCH37370,SCH N-acetyl base loratadine Desloratadine impurity III (Desloratadine n-acetyl impurity)" SCH-37370, 10 mM in DMSO PegCNTF Sch 1-(4-(8-chloro-5H-benzo[5,6]cyclohta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)ethanone 1-[4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]ethanone Desloratadine N-Acetyl Impurity Desloratadine N-Acetyl Impurity Loratadine Impurity 11 N-Acetyldesloratadine N Acetyldesloratadine |
| Description | N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1]. |
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| Related Catalog | |
| References |
| Density | 1.257g/cm3 |
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| Boiling Point | 546.9ºC at 760mmHg |
| Molecular Formula | C21H21ClN2O |
| Molecular Weight | 352.85700 |
| Flash Point | 284.5ºC |
| Exact Mass | 352.13400 |
| PSA | 33.20000 |
| LogP | 4.21570 |
| Vapour Pressure | 5.15E-12mmHg at 25°C |
| Index of Refraction | 1.626 |
| Storage condition | -20°C |
| Precursor 10 | |
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| DownStream 0 | |