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Shanghai Jizhi Biochemical Technology Co., Ltd
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ShangHai DC Chemicals Co.,Ltd
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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145-42-6

145-42-6 structure

Name: Sodium taurocholate
Chemical Name: sodium taurocholate
CAS Number: 145-42-6
Molecular Formula: C₂₆H₄₄NNaO₇S
Molecular Weight: 537.685
Catalog: API Digestive system medication Biliary medicine
Create Date: 2018-04-25 08:00:00
Modify Date: 2024-01-02 15:52:55
Taurocholic acid sodium (Sodium taurocholate; N-Choloyltaurine sodium) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Immunoregulation effect[1].

Name	sodium taurocholate
Synonyms	Taurine, N-choloyl-, monosodium salt monosodium N-choloyltaurinate sodium N-choloyltaurinate Sodium 2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)ethanesulfonate MFCD00013050 ethanesulfonic acid, 2-[[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1) Taurocholic Acid Sodium Salt from Bovine Bile froM Bovine Bile taurocholatesodiumsalt Sodium 2-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate Ethanesulfonic acid, 2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1) taurocholic acid sodium salt Sodium taurocholate taurocholatesodium Bile Salts (10 g) TAUROCHOLIC ACID NA-SALT 2-{[(3α,5β,7α,8ξ,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]amino}éthanesulfonate de sodium taurocholate sodium taurocholate sodiuM sal Natrium-2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)ethansulfonat Sodium Taurocholate from Bovine Bile Natrium-2-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethansulfonat Taurocholic acid Monosodium 2-(((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)ethanesulfonate EINECS 205-653-7 Sodium 2-{[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate taurocholate sodium salt taurochlolic acid sodium salt Ethanesulfonic acid, 2-(((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, monosodium salt Taurocholic sodium 2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-diméthylhexadécahydro-1H-cyclopenta[a]phénanthrén-17-yl]pentanoyl}amino)éthanesulfonate de sodium Taurine, N-choloyl-, sodium salt Sodium taurocholate hydrate

Description	Taurocholic acid sodium (Sodium taurocholate; N-Choloyltaurine sodium) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Immunoregulation effect[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	Microbial Metabolite Human Endogenous Metabolite
References	[1]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22.

Melting Point	230 °C
Molecular Formula	C₂₆H₄₄NNaO₇S
Molecular Weight	537.685
Exact Mass	537.273621
PSA	155.37000
LogP	3.49720
Index of Refraction	23 ° (C=3, H2O)
Water Solubility	> 250 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WX0400000

CHEMICAL NAME :: Taurine, N-choloyl-, sodium salt

CAS REGISTRY NUMBER :: 145-42-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C26-H44-N-O7-S.Na

MOLECULAR WEIGHT :: 537.76

WISWESSER LINE NOTATION :: L E5 B666TJ A1 DQ E1 FY1&2VM2SWO KQ OQ &-NA- &42/32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,32,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80529 No. of Facilities: 126 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3026 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80529 No. of Facilities: 52 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 741 (estimated) No. of Female Employees: 544 (estimated)

Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	WX0400000

107-35-7

81-25-4

~89%

145-42-6

Literature: Venturoni, Francesco; Gioiello, Antimo; Sardella, Roccaldo; Natalini, Benedetto; Pellicciari, Roberto Organic and Biomolecular Chemistry, 2012 , vol. 10, # 20 p. 4109 - 4115

Precursor 2
107-35-7 81-25-4
DownStream 3
107-35-7 81-25-4 75-65-0

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