Sodium taurocholate

Modify Date: 2024-01-02 15:52:55

Sodium taurocholate structure	Common Name	Sodium taurocholate
	CAS Number	145-42-6	Molecular Weight	537.685
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₄₄NNaO₇S	Melting Point	230 °C
	MSDS	Chinese USA	Flash Point	N/A

Use of Sodium taurocholate

Taurocholic acid sodium (Sodium taurocholate; N-Choloyltaurine sodium) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Immunoregulation effect[1].

Name	sodium taurocholate
Synonym	More Synonyms

Description	Taurocholic acid sodium (Sodium taurocholate; N-Choloyltaurine sodium) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Immunoregulation effect[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	Microbial Metabolite Human Endogenous Metabolite
References	[1]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22.

Melting Point	230 °C
Molecular Formula	C₂₆H₄₄NNaO₇S
Molecular Weight	537.685
Exact Mass	537.273621
PSA	155.37000
LogP	3.49720
Index of Refraction	23 ° (C=3, H2O)
Water Solubility	> 250 g/L (20 ºC)

Sodium taurocholate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WX0400000

CHEMICAL NAME :: Taurine, N-choloyl-, sodium salt

CAS REGISTRY NUMBER :: 145-42-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C26-H44-N-O7-S.Na

MOLECULAR WEIGHT :: 537.76

WISWESSER LINE NOTATION :: L E5 B666TJ A1 DQ E1 FY1&2VM2SWO KQ OQ &-NA- &42/32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,32,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80529 No. of Facilities: 126 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3026 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80529 No. of Facilities: 52 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 741 (estimated) No. of Female Employees: 544 (estimated)

Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	WX0400000

Taurine

CAS#:107-35-7

cholic acid

CAS#:81-25-4

~89%

Sodium taurocholate

CAS#:145-42-6

Literature: Venturoni, Francesco; Gioiello, Antimo; Sardella, Roccaldo; Natalini, Benedetto; Pellicciari, Roberto Organic and Biomolecular Chemistry, 2012 , vol. 10, # 20 p. 4109 - 4115

Precursor 2
CAS#:107-35-7 Taurine CAS#:81-25-4 cholic acid
DownStream 3
CAS#:107-35-7 Taurine CAS#:81-25-4 cholic acid CAS#:75-65-0 tert-Butanol

Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol.

J. Physiol. 593(8) , 2097-109, (2015)

Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensin...

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.

AAPS J. 16(4) , 875-83, (2014)

The effect of food intake on the release and degradation of peptide drugs from solid lipid particles is unknown and was therefore investigated in vitro using different fed state media in a lipolysis m...

Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly.

PLoS ONE 9(8) , e105073, (2014)

Royal jelly (RJ) intake lowers serum cholesterol levels in animals and humans, but the active component in RJ that lowers serum cholesterol level and its molecular mechanism are unclear. In this study...

Taurine, N-choloyl-, monosodium salt

monosodium N-choloyltaurinate

sodium N-choloyltaurinate

Sodium 2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)ethanesulfonate

MFCD00013050

ethanesulfonic acid, 2-[[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)

Taurocholic Acid Sodium Salt from Bovine Bile

froM Bovine Bile

taurocholatesodiumsalt

Sodium 2-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate

Ethanesulfonic acid, 2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)

taurocholic acid sodium salt

Sodium taurocholate

taurocholatesodium

Bile Salts (10 g)

TAUROCHOLIC ACID NA-SALT

2-{[(3α,5β,7α,8ξ,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]amino}éthanesulfonate de sodium

taurocholate sodium

taurocholate sodiuM sal

Natrium-2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)ethansulfonat

Sodium Taurocholate from Bovine Bile

Natrium-2-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethansulfonat

Taurocholic acid

Monosodium 2-(((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)ethanesulfonate

EINECS 205-653-7

Sodium 2-{[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate

taurocholate sodium salt

taurochlolic acid sodium salt

Ethanesulfonic acid, 2-(((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, monosodium salt

Taurocholic sodium

2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-diméthylhexadécahydro-1H-cyclopenta[a]phénanthrén-17-yl]pentanoyl}amino)éthanesulfonate de sodium

Taurine, N-choloyl-, sodium salt

Sodium taurocholate hydrate