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81-07-2

81-07-2 structure
81-07-2 structure
Name saccharin
Synonyms 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide
Sacchin, Powder
3-hydroxybenzisothiazole-s,s-dioxide
T56 BSWMVJ
O-SULFOBENZIMIDE
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide
UNII-FST467XS7D
2-Sulfobenzoicimide
1,2-Benzisothiazoline-3-one 1,1-dioxide
550 Sacchine
o-Benzoic acid sulfimide
EINECS 201-321-0
1,2-benzisothiazol-3(2h)-one1,1-dioxide
Kandiset
2-sulphobenzoicimide
o-SuL
1,1-dioxo-1,2-benzisothiazol-3-one
SACCHIN
o-Benzoic Sulfimide Sacchin
1,2-benzisothiazolinone,1,1-dioxide
1,2-Benzisothiaxol-3(2H)-one
1,2-Dihydro-2-ketobenzisosu
Benzo-2-sulphimide
Gluside
1,1-Diox-1,2-benzisothiazol-3-one
1,1-Dioxo-1,2-benzisothiazol-3(2H)-one
1,1-Dioxo-1,2-dihydro-benzo[d]isothiazol-3-one
Sacchin, R
Benzo-2-sulfiide
SACCHARINOL
2,3-Dihydro-3-oxobenzisosulphonazole
MFCD00005866
SACCHINE
1,2-Benzothiazol-3(2H)-one 1,1-dioxide
Sykose
Mettler-Toledo Calibration substance ME 51143091, Sacchin
2,3-Dihydro-3-oxobenzisosulfonazole
1,2-benzoisothiazolin-3-one1,1-dioxide
SACCHIN(P)
Saccharinose
Saccharol
Sacarina
SACCHIN INSOLUBLE
O-BENZOIC ACID SULFIMIDE
1, 2-benzisothiazole-3(2H)-one, 1,1-dioxide
Sweeta
1,2-Dihydro-2-ketobenzisosulphonazole
Saxin
1,1-Dioxide,2,3-dihydro-3-oxobenxisosulfonazole
3-Benzisothiazolinone 1,1-dioxide
SACCHINE INSOLUBLE
2-Sulphobenzoic imide
3-Hydroxybenzisothiazole S,S-dioxide
crystal insoluble sacchin
O-BENZOIC SULFIMIDE
Benzisosulfonazole, 2,3-dihydro-3-oxo
SYNCAL (R) SDI
Syncal
Natreen
1,1-dioxo-benzo[d]isothiazol-3-one
1,2-benzisothiazol-3(2H)-one-1,1-dioxide
2,3-Dihydro-1,2-benzoisothiazol-3-one-1,1-dioxide
benzoicsulfimide
1,1-Dioxide-1,2-benzisothiazol-3(2H)-one
Benzo[d]isothiazol-3(2H)
Sacchin,2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide
1,2-benzoisothiazol-3(2H)-one 1,1-dioxide
o-benzoic sulfimide
Benzoic sulfimide
1,2-benzisothiazol-3-one 1,1-dioxide
Glycosin
Benzo[d]isothiazol-3(2H)-one 1,1-dioxide
Garantose
3-benzisothiazolinone1,1-dioxide
o-Benzoic acid sulfiMide (Sacchin)
1,2-benzisothiazolin-3-one,1,1-dioxide
SACCHIN 550X
1,2-Benzisothiazol-3(2H)-one,1,1-dioxide
fobenzimide
1,2-Benzisothiazolin-3-one, 1,1-dioxide
Glucid
High purity insoluble sacchin
Description Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties[1].
Related Catalog
In Vitro In vitro, saccharin (0.5, 2.5, 5 mM) inhibits bacterial growth in a species-dependent manner[1].
In Vivo In vivo, saccharin (oral; 5 mg/kg; twice a day) intake reduces fecal bacterial load and alters microbiome composition, while the intestinal barrier is not obviously affected in male C57BL/6JRj wild type (wt) mice[1].
References

[1]. Sünderhauf A, et al. Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice. Nutrients. 2020 Apr 17;12(4). pii: E1122.
Density 1.7±0.1 g/cm3
Boiling Point 438.9±28.0 °C at 760 mmHg
Melting Point 226-229 °C(lit.)
Molecular Formula C7H5NO3S
Molecular Weight 183.184
Flash Point 219.3±24.0 °C
Exact Mass 182.999008
PSA 71.62000
LogP 0.46
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.714
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility 3.3 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE4200000
CHEMICAL NAME :
1,2-Benzisothiazolin-3-one, 1,1-dioxide
CAS REGISTRY NUMBER :
81-07-2
LAST UPDATED :
199701
DATA ITEMS CITED :
52
MOLECULAR FORMULA :
C7-H5-N-O3-S
MOLECULAR WEIGHT :
183.19
WISWESSER LINE NOTATION :
T56 BSWMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
365 gm/kg/1Y-I
TOXIC EFFECTS :
Blood - normocytic anemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2008 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
548 gm/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9600 mg/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
16800 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
101 gm/kg
SEX/DURATION :
female 1-21 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
252 gm/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
155 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
100 mg/L
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 45,769,1982 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,111,1980 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,111,1980 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,334,1987 TOXICOLOGY REVIEW PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958- Volume(issue)/page/year: 18,306,1975 TOXICOLOGY REVIEW TOANDB Toxicology Annual. (New York, NY) 1974/75-79. Discontinued. Volume(issue)/page/year: -,71,1974 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,81,1975 TOXICOLOGY REVIEW WMWOA4 Wiener Medizinische Wochenschrift. (Brueder Hollinek, Gallgasse 40, A-1130 Vienna, Austria) V.1- 1851- Volume(issue)/page/year: 121,515,1971 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 25,173,1978 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,129,1983 TOXICOLOGY REVIEW NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266, Phildelphia, PA 19103) V.1- 1978- Volume(issue)/page/year: 3,109,1981 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,674,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80507 No. of Facilities: 1556 (estimated) No. of Industries: 37 No. of Occupations: 36 No. of Employees: 44968 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80507 No. of Facilities: 7348 (estimated) No. of Industries: 107 No. of Occupations: 73 No. of Employees: 225094 (estimated) No. of Female Employees: 97727 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn:Harmful
Risk Phrases R40
Safety Phrases S24/25
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS DE4200000
HS Code 2925110000
HS Code 2925110000
Summary HS: 2925110000. benzo[d]isothiazol-3(2h)-one 1,1-dioxide. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:9.0%. general tariff:90.0%
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