21178-57-4

21178-57-4 structure

Name: 10,11-Dehydrocurvularin
Chemical Name: (5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione
CAS Number: 21178-57-4
Molecular Formula: C₁₆H₁₈O₅
Molecular Weight: 290.31100
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2016-05-30 08:47:26
Modify Date: 2026-08-06 22:25:03
10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].

Name	(5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione
Synonyms	Dehydrocurvularin 10，11-dehydro Curvulin (α，β-dehydro Curvulin) 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7-tetrahydro-11,13-dihydroxy-4-methyl-, (4S,8E) (S)-10,11-Dehydrocurvulin 8-dehydrocurvularin trans-dehydrocurvularin ALPHA,BETA-DEHYDROCURVULIN 10,11-dehydrocurvularin trans-Dehydrocurvulin AmbotzLS-1091 E-dehydrocurvularin 4,5,6,7-TETRAHYDRO-11,13-DIHYDROXY-4-METHYL-2H-3-BENZOXACYCLODODECIN-2,10-(1H)-DIONE (5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1,9,13,15-tetraene-3,11-dione

Description	10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
References	[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47. [2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.

HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%