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35065-27-1

35065-27-1 structure
35065-27-1 structure
Name 2,2',4,4',5,5'-hexachlorobiphenyl
Synonyms 2,2',4,4',5,5'-heptachlorobiphenyl
PCB 153
2,2',3,3',5,6'-HEXACHLOROBIPHENYL
HCBP
biphenyl, 2,2’,4,4’,5,5’-hexachloro-
CB-153
2,2',4,4',5,5'-Hexachloro-1,1'-biphenyl
2,2',4,4',5,5'-PCB
1,1'-Biphenyl,2,2',4,4',5,5'-hexachloro
2,2',4,4',5,5'-Hexachloro-1,1'-biphenyl (9CI)
PCB-153
Biphenyl, 2,2',4,4',5,5'-hexachloro-
2,2',4,4',5,5'-Hexachlorobiphenyl
1,1'-Biphenyl, 2,2',4,4',5,5'-hexachloro-
1,2,4-trichloro-5-(2,4,5-trichlorophenyl)benzene
2,4,5,2',4',5'-Hexachlorobiphenyl
2,2',4,4',5,5'-hexachloromobiphenyl
2,2′,4,4′,5,5′-Hexachlorobiphenyl
Density 1.6±0.1 g/cm3
Boiling Point 396.2±37.0 °C at 760 mmHg
Melting Point 103-104ºC
Molecular Formula C12H4Cl6
Molecular Weight 360.878
Flash Point 193.2±23.9 °C
Exact Mass 357.844421
LogP 6.83
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.627
Storage condition 2-8°C
Stability Thermally stable and resistant to both oxidation and biological degradation.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DV5350000
CHEMICAL NAME :
1,1'-Biphenyl, 2,2',4,4',5,5'-hexachloro-
CAS REGISTRY NUMBER :
35065-27-1
LAST UPDATED :
199712
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C12-H4-Cl6
MOLECULAR WEIGHT :
360.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
370 mg/kg/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in thymus weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
322 mg/kg/13W-C
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg/3D-I
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
960 mg/kg/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
1470 mg/kg/21D-C
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3650 mg/kg/104W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 8-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
448 mg/kg
SEX/DURATION :
female 10-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
112 mg/kg
SEX/DURATION :
female 10-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
448 mg/kg
SEX/DURATION :
female 10-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
120 mg/kg
SEX/DURATION :
female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
78 mg/kg
SEX/DURATION :
female 5-21 day(s) after conception lactating female 22 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
200 mg/kg
SEX/DURATION :
female 13-21 day(s) after conception lactating female 24 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
271 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1080 mg/kg
SEX/DURATION :
female 45-62 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
TYPE OF TEST :
DNA adduct

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
36400 ug/kg/5D
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 27,99,1979
Symbol GHS08 GHS09
GHS08, GHS09
Signal Word Warning
Hazard Statements H373-H410
Precautionary Statements P273-P391-P501
Personal Protective Equipment Eyeshields;Gloves
Hazard Codes F: Flammable;Xi: Irritant;N: Dangerous for the environment;Xn: Harmful;
Risk Phrases R11
Safety Phrases 16-26-33-36-61-60-35-62-29-9
RIDADR UN 2315
Packaging Group II
Hazard Class 9
HS Code 2903999090
HS Code 2903999090
Summary 2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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