676596-65-9
676596-65-9 structure
- Name: 1-Azakenpaullone
- Chemical Name: 1-Azakenpaullone
- CAS Number: 676596-65-9
- Molecular Formula: C15H10BrN3O
- Molecular Weight: 328.163
- Catalog: Biochemical Inhibitor PI3K/Akt/mTOR inhibitor (PI3K/Akt/mTOR) GSK-3 inhibitor
- Create Date: 2017-08-14 09:13:46
- Modify Date: 2025-08-24 01:48:07
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1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1].
| Name | 1-Azakenpaullone |
|---|---|
| Synonyms |
Pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 9-bromo-7,12-dihydro-
azakenpaullone 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one 9-Bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one 1-Azakenpaullone Kinome_3492 HMS3229B07 |
| Description | 1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
GSK-3β:18 nM (IC50) CDK1/cyclin B:2 μM (IC50) CDK5/p25:4.2 μM (IC50) |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 648.8±50.0 °C at 760 mmHg |
| Melting Point | >290ºC (dec.) |
| Molecular Formula | C15H10BrN3O |
| Molecular Weight | 328.163 |
| Flash Point | 346.2±30.1 °C |
| Exact Mass | 327.000702 |
| PSA | 57.78000 |
| LogP | 3.19 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.740 |
| Storage condition | -20°C Freezer |
| Water Solubility | DMSO: >10mg/mL |
| RIDADR | NONH for all modes of transport |
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