108930-17-2

108930-17-2 structure

Name: H7
Chemical Name: 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride
CAS Number: 108930-17-2
Molecular Formula: C₁₄H₁₉Cl₂N₃O₂S
Molecular Weight: 364.291
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2018-07-22 15:04:41
Modify Date: 2025-08-24 08:17:59
PKC-IN-5 (compound H-7) is a potent PKC (protein kinase C) inhibitor. At 100 μM, PKC-IN-5 completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase)[1].

Name	1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride
Synonyms	UNII:55VT8U9HB1 Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-, dihydrochloride 5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline dihydrochloride 1-(5-Isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride 5-[(2-Methylpiperazin-1-yl)sulfonyl]isoquinoline dihydrochloride Isoquinoline, 5-[(2-methyl-1-piperazinyl)sulfonyl]-, hydrochloride (1:2) 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine Dihydrochloride MFCD00036961 H-7 DIHYDROCHLORIDE 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride

Description	PKC-IN-5 (compound H-7) is a potent PKC (protein kinase C) inhibitor. At 100 μM, PKC-IN-5 completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase)[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
References	[1]. Fischer SM, et al. Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C. Toxicol In Vitro. 1989;3(3):195-9.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%