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Product Name: Sodium hyaluronate
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9067-32-7

9067-32-7 structure

9067-32-7 structure

Name: Sodium Hyaluronate
Chemical Name: Sodium hyaluronate
CAS Number: 9067-32-7
Molecular Formula: C₁₄H₂₂NNaO₁₁
Molecular Weight: 799.63800
Catalog: Biochemical Enzymes and coenzymes
Create Date: 2018-05-28 08:00:00
Modify Date: 2026-06-30 14:37:09
Hyaluronic acid sodium salt is a biopolymer composed of repeating units of disaccharides with various applications.

Name	Sodium hyaluronate
Synonyms	SODIUM HYALURONATE INJECTABLE ADE LMW HYALURONIC ACID SODIUM FROM ROOSTERCOMB Sodium Hyaluronate(HA) HYALURONIC ACID SODIUM FROMSTRTOCOCCU S ZOOIDEM Hyaluronic acid sodium salt from Strtococcus Sph HYALURONIC ACID SODIUM SALT FROM ROO hyaluronic acid sodium salt from human umbilical cord hyaluronic SODIUM HYALURONATE OPHTHALMIC ADE MMW SODIUM HYALURONATE COSMETIC ADE LMW SODIUM HYALURONATE PHMACEUTICAL ADE (MMW) SODIUM HYALURONATE COSMETIC ADE HMW HYALURONIC ACID - FOOD hyaluronic acid sodium salt HYALURONIC ACID ADE B ( HA-Q ) Hyaluronic acid-Na-salt from rooster comb HYALURONIC ACID INJECTABLE cockscomb Si-4402 SODIUM HYALURONATE(TOPICAL ADE) Hyaluronesodium Hyaluronate Sodium [USAN:JAN] hyaluronic acid sodium salt from strtococcus equi Food ade SodiuM hyaluronate Hyasis 850P HYALURONIC ACID LOW ENDOTOXIN Hyaluronate HYALURONIC ACID - COSMETIC HYALURONIC ACID LOW MOL (10,000) hyaluronic acid sodium salt from strtococcus zooidemicus Hyaluronic Acid Sodium Salt from Cockscomb HYALURONIC ACID HA-L510 PF SODIUM HYALURONATE PHMACEUTICAL ADE (HMW) HYALURONIC ACID ADE A ( HA-QSS ) EINECS 232-678-0 MFCD00875848 SODIUM HYALURONATE COSMETIC ADE MMW SODIUM HYALURONATE OPHTHALMIC ADE LMW Sl-1010 HYALURONIC ACID SODIUM SALT 2,000,00 HYALURONIC ACID SODIUM SALT F. STRTO-C OCCUS EQUI SP Sodium 4-O-(2-acetamido-2,3-dideoxy-β-D-ribo-hexopyranosyl)-β-D-glucopyranuronate SODIUM HYALURONATE OPHTHALMIC ADE HMW SODIUM HYALURONATE INTRATICULADE HMW Injection ade SodiuM hyaluronate β-Sodium glucuronate-(1,3)-β-N-acetyl-D-glucosamine HYALURONIC ACID SODIUM SALT 8 Medical ade SodiuM hyaluronate Hyaluronic Acid Sodium Salt from Microorganism HYALURONIC ACID - EYE DROP HYALURONIC ACID SODIUM SALT FROM STR SODIUM HYALURONATE SOLUTION HYALURONIC ACID - INJECTION Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating Sodium hyaluronate HYALURONIC ACID LMW hyaluronic acid sodium salt from rooster comb Chlamyhyaluronic acid sodium salt SODIUMHYALURINATE SODIUM HYALURONATE PHMACEUTICAL ADE (LMW) β-D-Glucopyranuronic acid, 4-O-[2-(acetylamino)-2,3-dideoxy-β-D-ribo-hexopyranosyl]-, sodium salt (1:1) alternating copoly(β-glucuronic acid-[1→3]-β-n-acetylglucosamine-[1→4]) HYALURONIC ACID EYE DROPS

Description	Hyaluronic acid sodium salt is a biopolymer composed of repeating units of disaccharides with various applications.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Saccharides and Glycosides Research Areas >> Cancer
In Vitro	Hyaluronic acid (HA) is widely used in aesthetic medicine due to its binding ability with a large number of water molecules. It improves tissue hydration and their resistance to mechanical damage. HA plays an important role in wound healing, ovulation, fertilization, signal transduction, and tumor physiology. HA is used in joint diseases such as osteoarthritis or rheumatoid arthritis. HA of a high molecular mass reduces the chemotaxis and migration of inflammatory cells which acts as a good barrier to the inflammatory process and protects against the effects of free radicals. HA is used in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicate its role in tumor markers, liver diseases, and in pharmaceuticals[1]. Hyaluronan plays an important role in cancer growth and metastasis. HA and HA fragment-tumor cell interaction could activate the downstream signaling pathways, promoting cell proliferation, adhesion, migration and invasion, and inducing angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like property, and chemoradioresistance in digestive cancers[2].
In Vivo	The impact of applied intra-articular HA has been proven in many studies in animals. Studies on HA have shown that it promotes the synthesis of cartilage matrix, prevents its degradation, reduces inflammation, stimulates the synthesis of endogenous HA, and improves the resilience and moisture of cartilage[1]. High molecular size HA preparations, applied topically, promote healing of fresh skin wounds. They also promote the healing of venous leg ulcers and are useful in the management of chronic wounds[3].
References	[1]. Salwowska NM, et al. Physiochemical properties and application of hyaluronic acid: a systematic review. J Cosmet Dermatol. 2016 Dec;15(4):520-526. [2]. Wu RL, et al. Hyaluronic acid in digestive cancers. J Cancer Res Clin Oncol. 2017 Jan;143(1):1-16. [3]. Kogan G, et al. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett. 2007 Jan;29(1):17-25.

Density	1.78g/cm3
Boiling Point	791.6ºC
Molecular Formula	C₁₄H₂₂NNaO₁₁
Molecular Weight	799.63800
Flash Point	432.5ºC
Exact Mass	799.22300
PSA	399.71000
Storage condition	−20°C
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	SOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MT7250000

CHEMICAL NAME :: Hyaluronic acid, sodium salt

CAS REGISTRY NUMBER :: 9067-32-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - other changes

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12,5369,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1770 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Blood - normocytic anemia

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12,5369,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Behavioral - ataxia Nutritional and Gross Metabolic - other changes

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12,5369,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,849,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 28,1013,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Behavioral - ataxia Nutritional and Gross Metabolic - other changes

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12,5369,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 19(Suppl 1),S13,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,849,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation Blood - normocytic anemia

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12,5369,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - other changes

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 12,5369,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2275 mg/kg/13W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in sodium Nutritional and Gross Metabolic - changes in chlorine

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 27,5809,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1680 mg/kg/4W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - normocytic anemia Blood - changes in leukocyte (WBC) count

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,2763,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 189 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Newborn - sex ratio

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,139,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 220 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - physical

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,111,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 77 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,111,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 660 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,111,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 91 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 29,131,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 52 mg/kg

SEX/DURATION :: male 91 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 28,1041,1984

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	22-24/25-36/37/39-27-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MT7250000
HS Code	3913900000

9004-61-9 structure

9004-61-9

~%

9067-32-7 structure

9067-32-7

Literature: WO2005/16341 A1, ; Page/Page column 3 ;

Precursor 1
9004-61-9
DownStream 1
9004-61-9

HS Code	3913900000

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