Name | 4,6-diphenyl-3,4-dihydro-1H-pyrimidine-2-thione |
---|---|
Synonyms |
4,6-diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione
HMS558F13 HMS2663P05 |
Description | KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1]. |
---|---|
Related Catalog | |
Target |
IC50: 19 μM (LOX-1)[1] |
In Vitro | KKII5 与腔体的 HIS499 相互作用,通过在分子的苯环和 HIS499 的咪唑环之间形成一个 π-π 堆叠相互作用[1]。 KKII5 (100 μM) 对脂质过氧化有明显抑制作用,抑制率达 98% [1]。 |
References |
Melting Point | 181-183ºC |
---|---|
Molecular Formula | C16H14N2S |
Molecular Weight | 266.36 |
Exact Mass | 266.08800 |
PSA | 56.15000 |
LogP | 3.90410 |
Risk Phrases | 36/37/38 |
---|---|
Safety Phrases | 26-36/37/39 |