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6381-55-1

6381-55-1 structure

6381-55-1 structure

Name: KKII5
Chemical Name: 4,6-diphenyl-3,4-dihydro-1H-pyrimidine-2-thione
CAS Number: 6381-55-1
Molecular Formula: C₁₆H₁₄N₂S
Molecular Weight: 266.36
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Phenylpyrimidine
Create Date: 2018-06-26 12:45:51
Modify Date: 2026-07-16 14:43:10
KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1].

Name	4,6-diphenyl-3,4-dihydro-1H-pyrimidine-2-thione
Synonyms	diphenyl-4,6 tetrahydro-1,2,3,4 thio-2 pyrimidine 4,6-diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione KKII5, 10 mM in DMSO 4,6-DIPHENYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2-THIONE 4,6-DIPHENYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2-THIONE ISO 9001：2015 REACH HMS558F13 HMS2663P05 4,6-Diphenyl-3,4-dihydropyrimidine-2(1H)-thione BUTTPK 116 2(1H)-Pyrimidinethione, 3,4-dihydro-4,6-diphenyl

Description	KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	IC50: 19 μM (LOX-1)[1]
In Vitro	KKII5 与腔体的 HIS499 相互作用，通过在分子的苯环和 HIS499 的咪唑环之间形成一个 π-π 堆叠相互作用[1]。 KKII5 (100 μM) 对脂质过氧化有明显抑制作用，抑制率达 98% [1]。
References	[1]. Georgiou N, et al. Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors. ACS Omega. 2023 Mar 21;8(13):11966-11977.

Melting Point	181-183ºC
Molecular Formula	C₁₆H₁₄N₂S
Molecular Weight	266.36
Exact Mass	266.08800
PSA	56.15000
LogP	3.90410

Risk Phrases	36/37/38
Safety Phrases	26-36/37/39

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