1282606-48-7

1282606-48-7 structure

Name: SCD1 inhibitor-3
Chemical Name: SCD1 inhibitor-3
CAS Number: 1282606-48-7
Molecular Formula: C₁₉H₁₆FN₇O₂
Molecular Weight: 393.37
Catalog: Signaling Pathways Metabolic Enzyme/Protease Stearoyl-CoA Desaturase (SCD)
Create Date: 2021-09-12 17:25:44
Modify Date: 2025-08-21 17:52:45
SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].

Name	SCD1 inhibitor-3

Description	SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD) Research Areas >> Metabolic Disease
Target	SCD1[1]
In Vivo	SCD1 inhibitor-3 (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %[1]. SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1]. Animal Model: Lewis rats Dosage: 5 mg/kg Administration: P.o.; 4 hours Result: Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %. Animal Model: Lewis rats Dosage: 2~10 mg/kg Administration: P.o.; 4 hours Result: A dose-responsive reduction of plasma triglycerides desaturation index.
References	[1]. Sun S, et al. Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem. 2015;23(3):455-465.

Molecular Formula	C₁₉H₁₆FN₇O₂
Molecular Weight	393.37