SCD1 inhibitor-3

Modify Date: 2025-08-21 17:52:45

SCD1 inhibitor-3 Structure
SCD1 inhibitor-3 structure
Common Name SCD1 inhibitor-3
CAS Number 1282606-48-7 Molecular Weight 393.37
Density N/A Boiling Point N/A
Molecular Formula C19H16FN7O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SCD1 inhibitor-3


SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].

 Names

Name SCD1 inhibitor-3

 SCD1 inhibitor-3 Biological Activity

Description SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].
Related Catalog
Target

SCD1[1]

In Vivo SCD1 inhibitor-3 (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %[1]. SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1]. Animal Model: Lewis rats Dosage: 5 mg/kg Administration: P.o.; 4 hours Result: Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %. Animal Model: Lewis rats Dosage: 2~10 mg/kg Administration: P.o.; 4 hours Result: A dose-responsive reduction of plasma triglycerides desaturation index.
References

[1]. Sun S, et al. Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem. 2015;23(3):455-465.

 Chemical & Physical Properties

Molecular Formula C19H16FN7O2
Molecular Weight 393.37
InChIKey FAIXKYSRYKWWGK-UHFFFAOYSA-N
SMILES O=C(NCc1cccnc1)c1cc(-n2cnn(Cc3ccc(F)cc3)c2=O)n[nH]1
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