1816272-19-1

1816272-19-1 structure

Name: WT IDH1 Inhibitor 2
Chemical Name: WT IDH1 Inhibitor 2
CAS Number: 1816272-19-1
Molecular Formula: C₂₈H₂₈FN₅O₃
Molecular Weight: 501.55
Catalog: Signaling Pathways Metabolic Enzyme/Protease Isocitrate Dehydrogenase (IDH)
Create Date: 2021-09-11 08:31:55
Modify Date: 2024-01-12 16:22:09
WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

Name	WT IDH1 Inhibitor 2

Description	WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)
Target	IC50: 120 nM (WT IDH1)[1]
In Vitro	WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].
References	[1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

Molecular Formula	C₂₈H₂₈FN₅O₃
Molecular Weight	501.55

Hazard Codes	Xi