WT IDH1 Inhibitor 2

Modify Date: 2025-08-27 07:49:59

WT IDH1 Inhibitor 2 Structure
WT IDH1 Inhibitor 2 structure
 Common Name WT IDH1 Inhibitor 2
CAS Number 1816272-19-1 Molecular Weight 501.55
Density N/A Boiling Point N/A
Molecular Formula C28H28FN5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of WT IDH1 Inhibitor 2


WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

 Names

Name WT IDH1 Inhibitor 2

 WT IDH1 Inhibitor 2 Biological Activity

Description WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].
Related Catalog
Target

IC50: 120 nM (WT IDH1)[1]

In Vitro WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].
References

[1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

 Chemical & Physical Properties

Molecular Formula C28H28FN5O3
Molecular Weight 501.55

 Safety Information

Hazard Codes Xi
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