2287153-38-0
2287153-38-0 structure
- Name: APJ receptor agonist 1
- Chemical Name: APJ receptor agonist 1
- CAS Number: 2287153-38-0
- Molecular Formula: C31H26ClN3O3
- Molecular Weight: 524.01
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2021-10-28 01:40:45
- Modify Date: 2024-02-04 08:27:18
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APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1].
| Name | APJ receptor agonist 1 |
|---|
| Description | APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1]. |
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| Related Catalog | |
| In Vitro | The S-atropisomer APJ receptor agonist 1 (compound 15a) is 200-fold more potent than the corresponding R-atropisomer.[1]. |
| In Vivo | APJ receptor agonist 1 (10-100 μg/min/kg; intravenous infusion) induces a 10% increase in CO with minimal impact on blood pressure (<5% transient blood pressure drop)[1]. Animal Model: Isoflurane-anesthetized male Sprague Dawley rats[1] Dosage: 10, 100, 1000 μg/kg/min Administration: IV; infused into the jugular vein for 15 min Result: Showed a dose-dependent improvement in the cardiac output in male Sprague Dawley rats with no significant changes in either mean arterial blood pressure or heart rate. |
| References |
| Molecular Formula | C31H26ClN3O3 |
|---|---|
| Molecular Weight | 524.01 |