APJ receptor agonist 1
Modify Date: 2025-08-25 07:45:53
APJ receptor agonist 1 structure
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Common Name | APJ receptor agonist 1 | ||
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| CAS Number | 2287153-38-0 | Molecular Weight | 524.01 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H26ClN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of APJ receptor agonist 1APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1]. |
| Name | APJ receptor agonist 1 |
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| Description | APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure[1]. |
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| Related Catalog | |
| In Vitro | The S-atropisomer APJ receptor agonist 1 (compound 15a) is 200-fold more potent than the corresponding R-atropisomer.[1]. |
| In Vivo | APJ receptor agonist 1 (10-100 μg/min/kg; intravenous infusion) induces a 10% increase in CO with minimal impact on blood pressure (<5% transient blood pressure drop)[1]. Animal Model: Isoflurane-anesthetized male Sprague Dawley rats[1] Dosage: 10, 100, 1000 μg/kg/min Administration: IV; infused into the jugular vein for 15 min Result: Showed a dose-dependent improvement in the cardiac output in male Sprague Dawley rats with no significant changes in either mean arterial blood pressure or heart rate. |
| References |
| Molecular Formula | C31H26ClN3O3 |
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| Molecular Weight | 524.01 |
| InChIKey | KCWRZNXFHSFVKD-UHFFFAOYSA-N |
| SMILES | CCCC(NC(=O)c1ccc(-c2c(Cl)cccc2-c2nc3ccccc3[nH]2)c(C(=O)O)c1)c1ccccc1 |