906366-79-8

906366-79-8 structure

Name: Inotilone
Chemical Name: 2-[(3,4-dihydroxyphenyl)methylidene]-5-methylfuran-3-one
CAS Number: 906366-79-8
Molecular Formula: C₁₂H₁₀O₄
Molecular Weight: 218.21
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2016-12-25 16:04:14
Modify Date: 2024-01-03 14:55:19
Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways[1].

Name	2-[(3,4-dihydroxyphenyl)methylidene]-5-methylfuran-3-one
Synonyms	2-[[3,4-bis(oxidanyl)phenyl]methylidene]-5-methyl-furan-3-one 2-[(3,4-dihydroxyphenyl)methylidene]-5-methyl-3-furanone inotilone

Description	Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP-2, MMP-9, NFκB p65, IκBα[1]
References	[1]. Chao W, et al. Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. Sci Rep. 2019 Feb 20;9(1):2344.