Inotilone
Modify Date: 2024-01-03 14:55:19
Inotilone structure
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Common Name | Inotilone | ||
|---|---|---|---|---|
| CAS Number | 906366-79-8 | Molecular Weight | 218.21 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H10O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of InotiloneInotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways[1]. |
| Name | 2-[(3,4-dihydroxyphenyl)methylidene]-5-methylfuran-3-one |
|---|---|
| Synonym | More Synonyms |
| Description | Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways[1]. |
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| Related Catalog | |
| Target |
MMP-2, MMP-9, NFκB p65, IκBα[1] |
| References |
| Molecular Formula | C12H10O4 |
|---|---|
| Molecular Weight | 218.21 |
| Exact Mass | 218.05800 |
| PSA | 66.76000 |
| LogP | 1.94180 |
| 2-[[3,4-bis(oxidanyl)phenyl]methylidene]-5-methyl-furan-3-one |
| 2-[(3,4-dihydroxyphenyl)methylidene]-5-methyl-3-furanone |
| inotilone |