484-76-4

484-76-4 structure

Name: Okanin
Chemical Name: okanin
CAS Number: 484-76-4
Molecular Formula: C₁₅H₁₂O₆
Molecular Weight: 288.25
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2017-01-21 01:43:43
Modify Date: 2025-08-21 10:36:40
Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways[1].

Name	okanin
Synonyms	3,4,2',3',4'-Pentahydroxy-trans-chalkon Okanin,2',3,3',4,4'-Pentahydroxychalcone 2',3,3',4,4'-Pentahydroxychalcone OKANIN (E)-3-(3,4-Dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl)-2-propen-1-one 2',3',4',3,4,-PENTAHYDROXYCHALCONE 2'.3'.4'.3.4-Pentahydroxy-chalkon 3,4,2',3',4'-pentahydroxy-trans-chalcone

Description	Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	TLR4 p65
In Vitro	Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells[1].
References	[1]. Hou Y, et al. Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Sci Rep. 2017 Apr 3;7:45705.

528-21-2

139-85-5

484-76-4

Literature: Kurth Journal of the American Chemical Society, 1939 , vol. 61, p. 861

56147-46-7

484-76-4

Literature: Russell; Todd Journal of the Chemical Society, 1934 , p. 1506

54917-85-0

484-76-4

Literature: Russell; Todd Journal of the Chemical Society, 1934 , p. 1506

Precursor 4
528-21-2 139-85-5 56147-46-7 54917-85-0
DownStream 0